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KMID : 0191120190340260181
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Journal of Korean Medical Science
2019 Volume.34 No. 26 p.181 ~ p.181
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Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
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Woo Jung-Min
Hong Jin-Pyo
Cho Seong-Jin
Lee Jun-Young
Joen Hong-Jin
Kim Byung-Soo
Chang Sung-Man
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Abstract
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Background: Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval.
Methods: Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates.
Results: PD elevated the risk of subsequent MDD by 1.5-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years.
Conclusion: The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.
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KEYWORD
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Lifetime Prevalence, Hazard Ratios, Composite International Diagnostic Interview, Age of Onset, Panic Disorder, Major Depressive Disorder
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